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TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma

Soji Toda1, Shinya Sato2, Nao Saito3

  • 1Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama 241-8515, Japan.

Cancers
|February 15, 2022
PubMed
Abstract

Insights

Anaplastic thyroid carcinoma (ATC) shows potential for new treatments. Trophoblast cell surface antigen 2 (TROP-2) and nectin-4 are promising targets, with glycoprotein non-metastatic B (GPNMB) and B7-H3 offering broader therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Development

Background:

  • Anaplastic thyroid carcinoma (ATC) is an aggressive cancer with limited treatment options.
  • Antibody-drug conjugates (ADCs) show promise in treating various carcinomas.
  • Expression of ADC targets in ATC is not well understood.

Purpose of the Study:

  • To investigate the expression of potential ADC targets in anaplastic thyroid carcinoma.
  • To identify novel therapeutic targets for ATC treatment.

Main Methods:

  • Tissue microarrays from 54 ATC patients were analyzed.
  • Immunohistochemical staining was performed for HER2, nectin-4, TROP-2, GPNMB, and B7-H3.
  • Expression levels were correlated with ATC subtypes.

Main Results:

  • HER2 was negative in all samples.
  • GPNMB and B7-H3 were expressed in most ATC tissues.
  • TROP-2 was found in 65% and nectin-4 in 59% of tissues.
  • TROP-2 expression varied by ATC subtype, as did nectin-4.

Conclusions:

  • TROP-2 and nectin-4 are potential targets for specific ATC subtypes.
  • GPNMB and B7-H3 may be viable targets for all ATC types.
  • These findings support the development of ADCs for ATC treatment.
Keywords:
ADCATCB7-H3GPNMBHER2Nectin-4TROP-2

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