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Updated: Oct 3, 2025
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
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Update on Management Recommendations for Advanced Cutaneous Squamous Cell Carcinoma
Jesús García-Foncillas1,2, Antonio Tejera-Vaquerizo3,4, Onofre Sanmartín5
1Departamento de Oncología, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain.
Cancers
|February 15, 2022
Summary
Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. Early detection, individualized treatment, and novel therapies like cemiplimab improve outcomes, but long-term surveillance is crucial due to recurrence risk.
Area of Science:
- Dermatology
- Oncology
Background:
- Cutaneous squamous cell carcinoma (cSCC) incidence is rising globally.
- While rarely metastasizing, cSCC can cause local invasion and progression.
- Prognostic factors for cSCC require further clarification regarding their impact on survival.
Purpose of the Study:
- To review current understanding and management of cSCC.
- To highlight advances in diagnostic and therapeutic strategies.
- To emphasize the importance of individualized patient care and surveillance.
Main Methods:
- Review of recent literature on cSCC diagnosis and treatment.
- Analysis of prognostic factors and their clinical significance.
- Evaluation of novel systemic therapies, including immunotherapies.
Main Results:
- Non-invasive imaging and molecular testing improve diagnostic accuracy.
- Surgical excision remains the primary treatment; radiotherapy is used for specific cases.
- Cemiplimab (anti-PD-1) is a key therapy for advanced/metastatic cSCC.
- Individualized treatment decisions are essential due to uncertain prognostic factor associations.
Conclusions:
- Advances in diagnostics and systemic therapies are transforming cSCC management.
- Personalized treatment approaches are critical for optimal patient outcomes.
- Long-term surveillance is necessary due to the risk of recurrence and new primary tumors.
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