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B.C.L. and immune response in mice

G M Sein

    The American Journal of Chinese Medicine
    |January 1, 1986
    PubMed

    The effects of Korean herbal medicine (B.C.L.) on some parameters of immunological response were studied in mice. B.C.L. pretreatment given either intraperitoneally or subcutaneously in a dose of 0.75 mg/mouse did not significantly inhibit lymphocyte transformation induced by concanavalin A. However, B.C.L. pretreatment in a dose of 2.25 mg/mouse was found to reduce significantly both the plaque-forming cells to sheep red blood cells immunisation as well as total spleen cell population. Thus, B.C.L. pretreatment with a higher dose (2.25 mg/mouse) can selectively depress the humoral immune response. It is unclear, however, whether this action is mediated by the parent compound or its metabolites.

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