Related Experiment Video

Updated: Oct 3, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
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Published on: March 8, 2018

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Antibody-Drug Conjugates as an Emerging Therapy in Oncodermatology

Clara Esnault1,2, David Schrama2, Roland Houben2

  • 1Team "Biologie des Infections à Polyomavirus", UMR INRAE ISP 1282, Université de Tours, 31 Avenue Monge, 37200 Tours, France.

Cancers
|February 15, 2022
PubMed

Insights

Antibody-drug conjugates (ADCs) offer targeted cancer cell killing. This review explores ADCs as a promising new treatment option for advanced skin cancers, addressing current therapy limitations.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Antibody-drug conjugates (ADCs) are approved for various cancers.
  • Advanced skin cancer treatments show progress but face resistance and side effects.
  • ADCs combine targeted antibody delivery with cytotoxic agents.

Purpose of the Study:

  • To review the design and development of ADCs.
  • To explore potential applications of ADCs in oncodermatology.

Main Methods:

  • Literature review of ADC design and development.
  • Analysis of current therapeutic strategies in oncodermatology.
  • Evaluation of ADC potential based on existing data.

Main Results:

  • ADCs offer targeted cytotoxicity to tumor cells.
  • ADCs represent an emerging therapeutic option for oncodermatology.
  • Review covers ADC design, development, and potential indications.

Conclusions:

  • ADCs show promise for overcoming resistance in advanced skin cancers.
  • Further research into ADC applications in oncodermatology is warranted.
Keywords:
antibody–drug conjugatescutaneous T-cell lymphoma and Merkel cell carcinomamelanomaoncodermatologyskin squamous cell carcinoma

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