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KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications

Flávia Pereira1,2,3,4, Anabela Ferreira1,2, Celso Albuquerque Reis3,5,6

  • 1Centre of Molecular and Environmental Biology (CBMA), Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.

Cells
|February 15, 2022
PubMed

Insights

KRAS mutations impact tumor cells and the tumor microenvironment (TME). This review clarifies their dual role in inflammation, offering new therapeutic strategies for KRAS-associated cancers.

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • KRAS mutations are common oncogenic drivers in pancreatic, colorectal, and lung cancers.
  • The tumor microenvironment (TME) significantly influences cancer progression and therapeutic response.
  • Understanding KRAS mutation effects on the TME is crucial for effective cancer treatment.

Purpose of the Study:

  • To elucidate the pro- and anti-inflammatory roles of KRAS mutations within the TME.
  • To detail the specific signaling pathways involved in KRAS-mediated TME modulation.
  • To explore novel therapeutic strategies targeting KRAS-driven inflammation.

Main Methods:

  • Literature review focusing on KRAS mutations and TME interactions.
  • Analysis of signaling pathways implicated in KRAS-driven inflammation.
  • Synthesis of current understanding of KRAS mutation impact on cancer immunity.

Main Results:

  • KRAS mutations exert complex, context-dependent effects on TME inflammation.
  • Specific signaling pathways mediate both pro- and anti-inflammatory responses.
  • The TME's inflammatory state influences therapeutic efficacy in KRAS-mutated cancers.

Conclusions:

  • KRAS mutations have a significant, multifaceted impact on the TME's inflammatory milieu.
  • Targeting KRAS-mediated inflammatory pathways may overcome therapeutic resistance.
  • Further research into KRAS-TME interactions can reveal new combination therapy approaches.
Keywords:
KRAS mutationscolorectal cancerinflammationlung cancerpancreatic cancertherapytumor microenvironment

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