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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Mesenchymal Stem Cell-Based COVID-19 Therapy: Bioengineering Perspectives.

Nihal Karakaş1,2, Süleyman Üçüncüoğlu2,3, Damla Uludağ2,4

  • 1Department of Medical Biology, School of Medicine, İstanbul Medipol University, İstanbul 34810, Turkey.

Cells
|February 15, 2022
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for treating COVID-19 lung inflammation. This review explores genetically engineered MSCs and bioengineering strategies to enhance their effectiveness against SARS-CoV-2 infection and its variants.

Keywords:
ACE2COVID-19SARS-CoV-2TMPRSS2bioengineeringgenetic engineeringmesenchymal stem cells

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Virology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a significant global health concern.
  • Mesenchymal stem cells (MSCs) are established treatments for pulmonary inflammatory conditions like ARDS and ALI.
  • Over 70 clinical trials are investigating MSCs for COVID-19, with promising preliminary results.

Purpose of the Study:

  • To review the therapeutic potential of functionally modified MSCs for COVID-19 treatment.
  • To explore bioengineering strategies for enhancing MSC efficacy against SARS-CoV-2 and its variants.
  • To provide perspectives on developing advanced MSC-based therapies for pulmonary diseases.

Main Methods:

  • Literature review of current MSC applications in pulmonary diseases.
  • Analysis of existing clinical trials for MSCs in COVID-19.
  • Exploration of genetic engineering and bioengineering techniques for MSC modification.

Main Results:

  • MSCs demonstrate significant therapeutic potential in preclinical and clinical settings for COVID-19.
  • Genetically engineered MSCs offer novel avenues for improved treatment efficacy.
  • Bioengineering tools can enhance MSCs' ability to combat SARS-CoV-2 infection and manage variants.

Conclusions:

  • Functionally modified MSCs represent a promising frontier in COVID-19 therapy.
  • Further research into bioengineered MSCs is crucial for optimizing treatment strategies.
  • Harnessing MSCs with advanced bioengineering holds potential for managing current and future SARS-CoV-2 challenges.