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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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Decrease in the Size of Fat-Enlarged Axillary Lymph Nodes and Serum Lipids after Bariatric Surgery.

Dennis Dwan1, Seth K Ramin2, Youdinghuan Chen3

  • 1Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.

Cells
|February 15, 2022
PubMed
Summary
This summary is machine-generated.

Bariatric surgery significantly reduced fat in axillary lymph nodes. This reduction was linked to improved dyslipidemia, independent of weight loss, highlighting a novel benefit of obesity surgery.

Keywords:
bariatric surgerydyslipidemiafat enlarged lymph nodeslymphatic dysfunctionobesityscreening mammography

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Area of Science:

  • Medical Science
  • Obesity Research
  • Lymphatic System Studies

Background:

  • Ectopic fat deposition in obesity is linked to organ dysfunction.
  • Limited knowledge exists regarding fat deposition within the lymphatic system and its dysfunction.

Purpose of the Study:

  • To investigate the impact of bariatric surgery on fat deposition in axillary lymph nodes.
  • To explore the relationship between changes in lymph node size and metabolic health indicators post-surgery.

Main Methods:

  • Retrospective review of 84 women undergoing bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy).
  • Evaluation of axillary lymph node size, weight, BMI, and comorbidities (hypertension, type 2 diabetes, dyslipidemia) before and after surgery.
  • Statistical analysis using binary linear regression and Fischer's exact test.

Main Results:

  • Fat-infiltrated axillary lymph nodes showed a significant size decrease (mean 4.23 mm) post-bariatric surgery (p < 0.001).
  • Resolution of dyslipidemia was independently associated with decreased lymph node size (p = 0.006).

Conclusions:

  • Bariatric surgery leads to a significant reduction in mammographically visualized fat in axillary lymph nodes.
  • The decrease in lymph node size is significantly associated with dyslipidemia resolution, independent of weight loss, age, or surgical type.