Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

2.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.9K
Inflammation01:38

Inflammation

55.9K
Overview
55.9K
What are Lipids?01:38

What are Lipids?

210.7K
Overview
210.7K
Lipid Absorption01:24

Lipid Absorption

1.0K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
1.0K
Lipids as Anchors01:32

Lipids as Anchors

6.1K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
6.1K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

5.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Matrix metalloprotease-9 modulates microglial/macrophage responses in murine brain demyelination.

Acta neuropathologica communications·2026
Same author

Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart.

Cellular and molecular life sciences : CMLS·2026
Same author

TRPV4 Deficiency Shifts Mitochondrial Dynamics Toward a Fragmented Morphology in Primary Microglia.

Cells·2026
Same author

Spinal cord reactive-antibodies identified by serological antigen selection show prognostic value in traumatic spinal cord injury patients.

Neurobiology of disease·2026
Same author

Lipid alterations in hereditary peripheral neuropathies: common mechanisms in disease heterogeneity?

Molecular neurodegeneration·2026
Same author

UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.

Nature communications·2025

Related Experiment Video

Updated: Oct 3, 2025

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
07:27

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

Published on: April 9, 2021

5.4K

Protein Lipidation by Palmitate Controls Macrophage Function.

Jeroen Guns1,2, Sam Vanherle1,2, Jerome J A Hendriks1,2

  • 1Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.

Cells
|February 15, 2022
PubMed
Summary

S-palmitoylation, a protein modification, is crucial for macrophage functions in health and disease. Targeting this process may offer new therapies for immune disorders.

Keywords:
S-palmitoylationinflammationinnate immunitymacrophagesprotein acetylation

More Related Videos

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
08:26

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Published on: October 31, 2017

9.4K
Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

694

Related Experiment Videos

Last Updated: Oct 3, 2025

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
07:27

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

Published on: April 9, 2021

5.4K
Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
08:26

Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

Published on: October 31, 2017

9.4K
Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

694

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Macrophages are vital immune cells involved in tissue homeostasis, pathogen clearance, and repair.
  • Their diverse functions require dynamic physiological regulation.
  • S-palmitoylation, a protein modification, is increasingly recognized for its role in cellular processes.

Purpose of the Study:

  • To provide a comprehensive review of S-palmitoylation's impact on macrophage physiology.
  • To explore the role of S-palmitoylation in key macrophage functions like endocytosis and inflammation.
  • To discuss the therapeutic potential of targeting S-palmitoylation in immune-related diseases.

Main Methods:

  • Literature review of studies investigating S-palmitoylation in macrophages.
  • Analysis of the molecular mechanisms by which S-palmitoylation affects protein function, stability, and trafficking.
  • Synthesis of findings related to S-palmitoylation in various macrophage-mediated cellular processes.

Main Results:

  • S-palmitoylation significantly influences macrophage endocytosis, inflammatory signaling, chemotaxis, and lysosomal function.
  • This modification regulates protein activity, stability, cellular localization, and interactions.
  • Dysregulation of S-palmitoylation is implicated in macrophage dysfunction during disease states.

Conclusions:

  • S-palmitoylation is a critical regulator of macrophage functions in both health and disease.
  • Modulators of S-palmitoylation represent a promising therapeutic strategy for immunopathologies.
  • Targeting S-palmitoylation could address a range of conditions, including infectious, inflammatory, and metabolic disorders.