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Biomarker Development in Cardiology: Reviewing the Past to Inform the Future
Katharine A Kott1,2,3, Michael Bishop4, Christina H J Yang3
1Cardiovascular Discovery Group, Kolling Institute of Medical Research, University of Sydney, St Leonards 2065, Australia.
Insights
Discovering new cardiac biomarkers is crucial for improving heart disease patient care. This review covers key protein biomarkers for acute coronary syndrome, heart failure, and atherosclerosis, and proposes a framework for future clinical trial evaluation.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Clinical Trials
Background:
- Cardiac biomarkers are essential in cardiology, yet significant potential for patient benefit remains unexplored.
- Existing biomarkers aid in diagnosing and managing cardiovascular conditions.
Purpose of the Study:
- To review the discovery and validation of key protein biomarkers for acute coronary syndrome, heart failure, and atherosclerosis.
- To examine statistical methods used for biomarker validation.
- To propose a framework for future biomarker discovery and evaluation in cardiovascular clinical trials.
Main Methods:
- Literature review of protein biomarker discovery in cardiology.
- Analysis of statistical approaches for biomarker validation.
- Overview of a proposed framework for integrating biomarker evaluation into clinical trials.
Main Results:
- Identified key protein biomarkers across acute coronary syndrome, heart failure, and atherosclerosis.
- Summarized populations studied and statistical validation methods used for these biomarkers.
- Highlighted current statistical approaches for assessing novel biomarkers.
Conclusions:
- Further discovery of cardiac biomarkers holds significant promise for advancing cardiology patient care.
- A structured framework for biomarker discovery and evaluation is needed for future cardiovascular outcome trials.
- Rigorous statistical validation is critical for implementing new biomarkers in clinical practice.
Abstract:
Cardiac biomarkers have become pivotal to the clinical practice of cardiology, but there remains much to discover that could benefit cardiology patients. We review the discovery of key protein biomarkers in the fields of acute coronary syndrome, heart failure, and atherosclerosis, giving an overview of the populations they were studied in and the statistics that were used to validate them. We review statistical approaches that are currently in use to assess new biomarkers and overview a framework for biomarker discovery and evaluation that could be incorporated into clinical trials to evaluate cardiovascular outcomes in the future.
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