Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Die hard: when cells refuse apoptosis-the rise of paraptosis and other death pathways.

Cell death discovery·2026

Same author

Fused Deposition Modeling of Polymer-Based Magnetic Composites from Recycled Permanent Magnets of Discarded Hard Drives.

Materials (Basel, Switzerland)·2026

Same author

Metabolic markers in bipolar disorder with childhood trauma exposure: a systematic review.

CNS spectrums·2026

Same author

Light-Activated Qubit Coupling in a Vanadyl Porphyrin Trimer.

Journal of the American Chemical Society·2026

Same author

Competitive Size Effects in Antiferromagnetic|Ferrimagnetic Core|Shell Nanoparticles for Large Exchange Bias.

ACS applied nano materials·2025

Same author

Correction to "Hardening of Cobalt Ferrite Nanoparticles by Local Crystal Strain Release: Implications for Rare Earth Free Magnets".

ACS applied nano materials·2025

Search research articles

Related Experiment Video

Updated: Oct 3, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Delivery.

Parisa Eslami¹, Martin Albino^1,2, Francesca Scavone³

¹INSTM and Dipartimento di Ingegneria Industriale-DIEF, Università degli Studi di Firenze, 50139 Sesto Fiorentino, Italy.

Nanomaterials (Basel, Switzerland)

|February 15, 2022

Summary

We developed smart magnetic nanocarriers for controlled drug delivery and hyperthermia cancer treatment. These nanocarriers release drugs effectively under specific pH and temperature conditions, enhancing treatment efficacy.

Keywords:

controlled drug release drug delivery magnetic hyperthermia magnetite nanoparticles pH-responsive nanocarriers thermo-responsive nanocarriers

More Related Videos

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

Published on: July 2, 2020

Related Experiment Videos

Last Updated: Oct 3, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

Published on: July 2, 2020

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Developing targeted drug delivery systems is crucial for effective cancer therapy.
Stimuli-responsive materials offer precise control over drug release and therapeutic action.
Magnetic nanoparticles enable localized hyperthermia for enhanced treatment outcomes.

Purpose of the Study:

To create dual pH- and temperature-responsive magnetic nanocarriers for controlled drug release and magnetic hyperthermia.
To encapsulate doxorubicin within these nanocarriers with high efficiency.
To evaluate the drug release profile under different stimuli and hyperthermia conditions.

Main Methods:

Synthesis of superparamagnetic iron oxide nanoparticles (magnetite) via the polyol approach.
Encapsulation of magnetite nanoparticles within a dual pH- and temperature-responsive poly (N-vinylcaprolactam-co-acrylic acid) copolymer.
Loading of doxorubicin and assessment of encapsulation efficiency at neutral pH.
Evaluation of doxorubicin release under acidic pH and/or elevated temperatures, including magnetic hyperthermia.

Main Results:

Flower-like magnetite nanoparticles (16.4 nm) with good magnetic properties were synthesized.
Magnetic nanocarriers exhibited reversible hydration/dehydration transitions responsive to acidic pH and temperatures above physiological levels.
Doxorubicin was loaded with high encapsulation efficiency (>96.0%) at neutral pH.
A burst release of doxorubicin was observed at acidic pH under hyperthermia conditions, with minimal release at neutral pH and physiological temperature.

Conclusions:

The developed multi-stimuli-sensitive nanoplatform demonstrates potential for remote-controlled drug delivery.
The combination of pH-responsiveness and magnetic hyperthermia enhances controlled drug release.
These magnetic nanocarriers are promising for targeted cancer treatment, integrating drug delivery and hyperthermia.