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Published on: August 16, 2018
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Methods to Produce Nicotinic Acid with Potential Industrial Applications
Dawid Lisicki1, Kinga Nowak1, Beata Orlińska1
1Department of Organic Chemical Technology and Petrochemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland.
Materials (Basel, Switzerland)
|February 15, 2022
Summary
Green chemistry demands new nicotinic acid production methods. This review explores eco-friendly industrial synthesis routes for nicotinic acid (vitamin PP) from readily available precursors, avoiding harmful by-products.
Area of Science:
- Green Chemistry
- Industrial Biotechnology
- Organic Synthesis
Background:
- Nicotinic acid (vitamin PP) is an essential nutrient and antipelagic agent.
- Current industrial production involves nitric acid oxidation, yielding nitrous oxide, a potent greenhouse gas.
- There is a critical need for sustainable, environmentally friendly nicotinic acid synthesis.
Purpose of the Study:
- To review ecological methods for nicotinic acid production.
- To identify industrially applicable green synthesis routes.
- To focus on raw materials like 3-methylpyridine and 5-ethyl-2-methylpyridine.
Main Methods:
- Comprehensive literature review of existing and emerging nicotinic acid synthesis technologies.
- Analysis of eco-friendly production pathways.
- Evaluation of methods for industrial scalability and environmental impact.
Main Results:
- Identified several potential green chemistry approaches for nicotinic acid synthesis.
- Highlighted methods utilizing 3-methylpyridine and 5-ethyl-2-methylpyridine as viable precursors.
- Assessed the environmental benefits compared to traditional methods.
Conclusions:
- New, greener industrial technologies for nicotinic acid production are feasible.
- Sustainable synthesis routes can mitigate environmental concerns associated with current practices.
- Further research into scaling these ecological methods is warranted.
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