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Published on: April 15, 2022
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Magnesium-Based Alloys Used in Orthopedic Surgery
Iulian Antoniac1,2, Marian Miculescu1, Veronica Mănescu Păltânea1,3
1Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania.
Materials (Basel, Switzerland)
|February 15, 2022
Summary
Magnesium (Mg)-based alloys show promise as biodegradable orthopedic implants, offering a safe alternative to permanent metal ones. Research covers their development, properties, and clinical success.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Materials Science
Background:
- Magnesium (Mg)-based alloys are increasingly researched as temporary orthopedic implants.
- They offer a biodegradable alternative to traditional nondegradable metal implants.
- Their development addresses limitations of current orthopedic materials.
Purpose of the Study:
- To provide a comprehensive overview of Mg-based alloys for orthopedic applications.
- To detail alloy development, manufacturing, and key properties.
- To review their physiological effects, mechanical performance, and clinical translation.
Main Methods:
- Literature review of Mg-based alloy development and manufacturing.
- Analysis of physiological, toxicological, and mechanical properties.
- Evaluation of osteogenesis, angiogenesis, biocompatibility, and clinical studies.
Main Results:
- Mg-based alloys exhibit potential for orthopedic implants due to biodegradability.
- Key attributes including mechanical properties, degradation, and biocompatibility are presented.
- In vitro and in vivo studies, including animal testing and clinical cases, demonstrate feasibility.
Conclusions:
- Mg-based alloys are a promising class of materials for temporary orthopedic implants.
- Further research and clinical translation are supported by existing data.
- These alloys represent a significant advancement in orthopedic biomaterials.
