Related Experiment Video

Updated: Oct 3, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

787

S100B Maternal Blood Levels in Gestational Diabetes Mellitus Are Birthweight, Gender and Delivery Mode Dependent

Laura Abella1, Ebe D'Adamo2, Mariachiara Strozzi3

  • 1Hospital Universitari Dexeus, 08028 Barcelona, Spain.

International Journal of Environmental Research and Public Health
|February 15, 2022
PubMed

Insights

Maternal S100B levels are elevated in pregnancies with Gestational Diabetes Mellitus (GDM), indicating potential fetal central nervous system (CNS) involvement. This protein may serve as a valuable marker for monitoring high-risk pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Neurology
  • Biochemistry

Background:

  • Gestational Diabetes Mellitus (GDM) significantly contributes to perinatal complications.
  • A reliable biomarker for fetal central nervous system (CNS) development and damage in GDM pregnancies is currently lacking.

Purpose of the Study:

  • To investigate the role of brain-protein S100B in maternal blood as a potential indicator of fetal CNS status in Gestational Diabetes Mellitus pregnancies.
  • To assess the correlation of S100B levels with gestational age, birth weight, and delivery mode in GDM cases.

Main Methods:

  • A prospective case-control study involving 646 pregnancies (106 GDM, 530 controls).
  • Maternal blood samples were collected at four time-points from 24 weeks gestation to term for S100B measurement.
  • Data was analyzed considering gender, delivery mode, gestational age, and birth weight.

Main Results:

  • Elevated S100B levels were observed in GDM fetuses compared to controls from 24 weeks gestation to term (p < 0.05).
  • Higher S100B levels were noted in male newborns and those born vaginally within the GDM group.
  • S100B positively correlated with gestational age (R = 0.27) and birth weight (R = 0.37) (p < 0.01).

Conclusions:

  • Maternal S100B shows promise as a biomarker for monitoring fetal CNS status in high-risk Gestational Diabetes Mellitus pregnancies.
  • Further research is warranted to explore S100B's potential as an early marker for CNS growth or damage in the GDM population.

Keywords:
S100Bbiomarkerbrain developmentfetusgestational diabetes mellitusnewbornpregnancy

More Related Videos

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.8K
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

9.8K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.4K
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
25.5K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
898
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
293