A Systematic Literature Review of Indoor Air Disinfection Techniques for Airborne Bacterial Respiratory Pathogens
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Published on: August 22, 2018
Thi Tham Nguyen1, Graham R Johnson2, Scott C Bell3,4,5
1School of Public Health, The University of Queensland, Herston, QLD 4006, Australia.
Abstract:
Interrupting the transmission of airborne (<≈5 µm) respiratory pathogens indoors is not a new challenge, but it has attracted unprecedented interest due to the COVID-19 pandemic during 2020-2021. However, bacterial respiratory pathogens with known or potential airborne transmission account for an appreciable proportion of the communicable disease burden globally. We aimed to systematically review quantitative, laboratory-based studies of air disinfection techniques for airborne respiratory bacteria. Three databases (PubMed, Web of Science, Scopus) were searched, following PRISMA guidelines. A total of 9596 articles were identified, of which 517 were assessed in detail and of which 26 met the inclusion and quality assessment criteria. Seven air disinfection techniques, including UV-C light, filtration, and face masks, among others, were applied to 13 different bacterial pathogens. More than 80% of studies suggested that air disinfection techniques were more effective at inactivating or killing bacteria than the comparator or baseline condition. However, it was not possible to compare these techniques because of methodological heterogeneity and the relatively small number of the studies. Laboratory studies are useful for demonstrating proof-of-concept and performance under controlled conditions. However, the generalisability of their findings to person-to-person transmission in real-world settings is unclear for most of the pathogens and techniques we assessed.
Insights
Air disinfection techniques show promise for reducing airborne bacteria, with over 80% of studies demonstrating effectiveness. However, comparing methods is difficult due to varied research and real-world applicability remains unclear.
Area of Science:
- Environmental microbiology
- Infectious disease control
- Public health
Background:
- Airborne respiratory pathogens pose a significant global health burden.
- The COVID-19 pandemic heightened interest in indoor airborne pathogen transmission control.
- Bacterial respiratory pathogens are a substantial component of communicable disease.
Purpose of the Study:
- To systematically review laboratory studies on air disinfection techniques for airborne respiratory bacteria.
- To assess the effectiveness of various air disinfection methods against bacterial pathogens.
- To identify gaps in current research regarding air disinfection efficacy.
Main Methods:
- Systematic literature search of PubMed, Web of Science, and Scopus databases.
- Inclusion of quantitative, laboratory-based studies following PRISMA guidelines.
- Detailed assessment of 517 articles, with 26 meeting inclusion and quality criteria.
Main Results:
- Seven air disinfection techniques (e.g., UV-C light, filtration, face masks) were evaluated against 13 bacterial pathogens.
- Over 80% of studies indicated that air disinfection techniques were more effective than control conditions.
- Methodological heterogeneity and limited study numbers prevented direct technique comparison.
Conclusions:
- Laboratory studies demonstrate proof-of-concept for air disinfection techniques against bacteria.
- The generalizability of laboratory findings to real-world settings requires further investigation.
- More standardized research is needed to compare the efficacy of different air disinfection methods.
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