Related Experiment Video
Updated: Oct 3, 2025
07:54
Cholesterol Efflux Assay
Published on: March 6, 2012
30.1K
Cholesterol Transport Dysfunction and Its Involvement in Atherogenesis
Anastasia V Poznyak1, Dmitry A Kashirskikh2, Vasily N Sukhorukov3
1Institute for Atherosclerosis Research, Osennyaya Street 4-1-207, 121609 Moscow, Russia.
International Journal of Molecular Sciences
|February 15, 2022
Summary
Disorders in cholesterol metabolism, particularly reverse cholesterol transport, contribute to atherosclerosis development. Understanding these processes is key to preventing cardiovascular disease and managing dyslipidemia.
Area of Science:
- Cardiovascular Science
- Metabolic Disorders
- Pathogenesis of Atherosclerosis
Background:
- Atherosclerosis is a primary cause of severe cardiovascular disorders, disability, and mortality.
- Key pathogenic processes include inflammation, endothelial dysfunction, oxidative stress, and lipid metabolism disruptions.
- High-density lipoprotein's (HDL) atheroprotective effect is linked to reverse cholesterol transport.
Purpose of the Study:
- To review cholesterol metabolism disorders and their impact on atherogenesis.
- To emphasize the role of reverse cholesterol transport in maintaining cellular cholesterol homeostasis.
- To explore the link between altered cholesterol metabolism, dyslipidemia, and early atherosclerosis.
Main Methods:
- Literature review focusing on cholesterol metabolism and atherogenesis.
- Analysis of the mechanisms involved in reverse cholesterol transport.
- Examination of low-density lipoprotein (LDL) modifications and foam cell formation.
Main Results:
- Transformed cholesterol metabolism leads to dyslipidemia and promotes early atherosclerosis.
- Modified LDL and subsequent foam cell formation are critical in atherosclerotic plaque development.
- Reverse cholesterol transport is an essential endogenous pathway for cellular cholesterol export.
Conclusions:
- Disruptions in cholesterol metabolism significantly contribute to the development of atherosclerosis.
- Reverse cholesterol transport plays a crucial role in preventing cholesterol accumulation and maintaining vascular health.
- Targeting cholesterol metabolism pathways may offer therapeutic strategies for cardiovascular disease prevention.
Related Concept Videos
01:29Cholesterol: Significance and Regulation
730
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
730
01:30Atherosclerosis I: Introduction
147
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
147
01:44The Significance of Membrane Transport
31.8K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
31.8K
01:31Lipid-derived Compounds in the Human Body
5.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.5K
01:18Lipids: Dietary Sources and Requirements
1.1K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.1K
01:26Coronary Artery Disease II: Pathophysiology
72
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
72