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Updated: Oct 3, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

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Published on: October 4, 2019

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Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

Amir Barzegar Behrooz1, Zahra Talaie1, Fatemeh Jusheghani2

  • 1Brain Cancer Department, Asu vanda Gene Industrial Research Company, Tehran 1533666398, Iran.

International Journal of Molecular Sciences
|February 15, 2022
PubMed

Insights

Glioblastoma (GBM) treatment needs new strategies. Targeting Wnt/β-catenin and PI3K/Akt/mTOR (PAM) pathways may disrupt GBM cell functions and improve patient survival.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options.
  • Current therapies offer palliative care, necessitating novel therapeutic strategies.
  • Understanding GBM progression drivers is crucial for developing targeted treatments.

Purpose of the Study:

  • To review the role of Wnt/β-catenin and PI3K/Akt/mTOR (PAM) signaling pathways in GBM.
  • To explore the potential of these pathways as therapeutic targets for GBM treatment.

Main Methods:

  • Literature review focusing on Wnt/β-catenin and PAM signaling in GBM.
  • Analysis of the involvement of these pathways in GBM cell proliferation, invasion, and angiogenesis.

Main Results:

  • Wnt/β-catenin and PAM pathways are critical regulators of GBM cell functions.
  • These pathways influence cell proliferation, epithelial-mesenchymal transition (EMT), metabolism, and angiogenesis in GBM.
  • Targeting components of Wnt/β-catenin and PAM pathways shows promise for disrupting GBM progression.

Conclusions:

  • Wnt/β-catenin and PAM pathways are pivotal in GBM invasion.
  • Targeting these signaling pathways offers a potential strategy for novel GBM therapeutics.
  • Further research into targeting Wnt/β-catenin and PAM pathways could enhance GBM patient survival rates.
Keywords:
GBM survivalPI3K/Akt/mTORWnt/β-cateninautophagyglioblastoma

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