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Updated: Oct 3, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Challenges in Discovering Drugs That Target the Protein-Protein Interactions of Disordered Proteins
Judit Oláh1, Tibor Szénási1, Attila Lehotzky1
1Institute of Enzymology, Research Centre for Natural Sciences, ELKH, 1117 Budapest, Hungary.
Abstract:
Protein-protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, however, the discovery of small molecules for use as drugs entails targeting individual proteins rather than targeting PPIs. This is largely because discovering small molecules to modulate PPIs has been seen as extremely challenging. Here, we review the difficulties and limitations of strategies to discover drugs that target PPIs directly or indirectly, taking as examples the disordered proteins involved in neurodegenerative diseases.
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