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Modernistic and Emerging Developments of Nanotechnology in Glioblastoma-Targeted Theranostic Applications
Buddolla Anantha Lakshmi1, Young-Joon Kim1
1Department of Electronic Engineering, Gachon University, Seongnam-Daero 1342, Incheon 13120, Korea.
Abstract:
Brain tumors such as glioblastoma are typically associated with an unstoppable cell proliferation with aggressive infiltration behavior and a shortened life span. Though treatment options such as chemotherapy and radiotherapy are available in combating glioblastoma, satisfactory therapeutics are still not available due to the high impermeability of the blood-brain barrier. To address these concerns, recently, multifarious theranostics based on nanotechnology have been developed, which can deal with diagnosis and therapy together. The multifunctional nanomaterials find a strategic path against glioblastoma by adjoining novel thermal and magnetic therapy approaches. Their convenient combination of specific features such as real-time tracking, in-depth tissue penetration, drug-loading capacity, and contrasting performance is of great demand in the clinical investigation of glioblastoma. The potential benefits of nanomaterials including specificity, surface tunability, biodegradability, non-toxicity, ligand functionalization, and near-infrared (NIR) and photoacoustic (PA) imaging are sufficient in developing effective theranostics. This review discusses the recent developments in nanotechnology toward the diagnosis, drug delivery, and therapy regarding glioblastoma.
Insights
Nanotechnology offers advanced theranostics for glioblastoma, overcoming blood-brain barrier challenges. These nanomaterials enable combined diagnosis and therapy, improving glioblastoma treatment strategies.
Area of Science:
- Oncology
- Nanomedicine
- Biotechnology
Background:
- Glioblastoma is an aggressive brain tumor characterized by rapid cell proliferation and infiltration.
- Current treatments like chemotherapy and radiotherapy are limited by the blood-brain barrier's impermeability.
- There is a critical need for innovative therapeutic strategies to effectively manage glioblastoma.
Purpose of the Study:
- To review recent advancements in nanotechnology for glioblastoma diagnosis and therapy.
- To highlight the potential of multifunctional nanomaterials in overcoming treatment challenges.
- To discuss the integration of thermal and magnetic therapy approaches using nanotechnology.
Main Methods:
- Review of current literature on nanotechnology applications in glioblastoma research.
- Analysis of nanomaterial properties relevant to drug delivery and imaging.
- Discussion of theranostic approaches combining diagnosis and treatment.
Main Results:
- Nanotechnology enables the development of multifunctional theranostics for glioblastoma.
- Nanomaterials offer enhanced features like real-time tracking, tissue penetration, and drug-loading capacity.
- Near-infrared (NIR) and photoacoustic (PA) imaging modalities are leveraged by nanomaterials.
Conclusions:
- Nanotechnology-based theranostics show significant promise for improved glioblastoma diagnosis and treatment.
- Multifunctional nanomaterials offer specificity, tunability, and biodegradability for effective therapeutic strategies.
- Further clinical investigation of nanotech-driven theranostics is warranted for glioblastoma management.
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