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Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines.
Zhikui Wei1, You Chen2, Raghu P Upender1
1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
International Journal of Molecular Sciences
|February 15, 2022
Summary
Adipokines, hormones crucial for metabolism, are linked to sleep disorders. This review explores how adipokines influence sleep and how sleep disturbances affect adipokine function, impacting metabolic health.
Area of Science:
- Endocrinology
- Metabolism
- Sleep Science
Background:
- Adipokines are key peptide hormones regulating whole-body metabolism.
- Sleep disturbance is associated with various metabolic disorders.
- Adipokines may mediate the link between sleep issues and metabolic problems.
Purpose of the Study:
- To review selected adipokines and their metabolic functions.
- To explore the roles of adipokines in sleep physiology and disorders.
- To synthesize findings from human and animal studies on adipokines and sleep.
Main Methods:
- Literature review of selected adipokines.
- Analysis of human and animal studies on adipokines, sleep physiology, and sleep disorders.
- Synthesis of evidence on the bidirectional relationship between adipokines and sleep.
Main Results:
- Adipokines exhibit multifaceted roles in sleep physiology and disorders.
- Sleep disturbances can alter adipokine function.
- Altered adipokine function due to sleep disturbance contributes to metabolic derangements.
Conclusions:
- Adipokines play a significant role in both sleep regulation and metabolic health.
- The interplay between adipokines and sleep is bidirectional.
- Understanding this relationship is crucial for addressing metabolic disorders linked to sleep disturbances.
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