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A Novel Method for the Culture and Polarized Stimulation of Human Intestinal Mucosa Explants
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Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii

Sandrine Auger1, Camille Kropp1, Esther Borras-Nogues1

  • 1Université Paris-Saclay, INRAE, AgroParisTech, Micalis, 78352 Jouy-en-Josas, France.

International Journal of Molecular Sciences
|February 15, 2022
PubMed

Insights

Microbial Anti-inflammatory Molecules (MAMs) from different Faecalibacterium prausnitzii strains show varied anti-inflammatory effects. This discovery aids in selecting F. prausnitzii strains for treating inflammatory diseases.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Faecalibacterium prausnitzii, a gut commensal, possesses anti-inflammatory properties.
  • These properties are partly attributed to its production of Microbial Anti-inflammatory Molecules (MAMs).
  • Previous research identified distinct phylogroups within F. prausnitzii strains.

Purpose of the Study:

  • To investigate whether MAMs from different F. prausnitzii phylogroups exhibit varying anti-inflammatory activities.
  • To explore the functional diversity within the family of MAM proteins.
  • To identify potential F. prausnitzii strains for probiotic applications in inflammatory diseases.

Main Methods:

  • Phylogenetic analysis of MAM-like proteins across various F. prausnitzii genomes.
  • Gene context analysis to classify MAMs into distinct clusters.
  • In vitro and in vivo (murine colitis models) evaluation of anti-inflammatory capacities of selected MAMs.

Main Results:

  • Identification of at least 10 distinct clusters of MAMs, suggesting functional diversity.
  • Significant variation in anti-inflammatory activity among tested MAMs, with one showing 96% inhibition and others much less.
  • In vivo confirmation of differential anti-inflammatory effects in murine models of colitis.

Conclusions:

  • MAMs produced by different F. prausnitzii phylogroups possess distinct anti-inflammatory potencies.
  • The study highlights the functional diversity within the MAM protein family.
  • Findings provide crucial insights for selecting specific F. prausnitzii strains as probiotics for managing chronic inflammatory conditions.
Keywords:
Faecalibacterium prausnitziimicrobial anti-inflammatory moleculeprobiotic

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