Related Experiment Video

Updated: Oct 3, 2025

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
08:00

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity

Published on: July 10, 2019

6.3K

The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure

Thomas Kubin1, Praveen Gajawada1, Peter Bramlage2

  • 1Department of Cardiac Surgery, Kerckhoff Heart Center, Benekestr. 2-8, 61231 Bad Nauheim, Germany.

International Journal of Molecular Sciences
|February 15, 2022
PubMed

Insights

Oncostatin M (OSM) signaling impacts heart remodeling. While short-term OSM receptor activation aids recovery, chronic signaling promotes heart failure, presenting therapeutic challenges.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Immunology

Background:

  • Oncostatin M (OSM), an interleukin-6 family cytokine, is a key mediator of cardiac remodeling in various heart diseases.
  • The OSM receptor (OSMR) signaling pathway is implicated in conditions like myocardial infarction and cardiomyopathies, making it a potential therapeutic target.
  • OSM's dual role in cardiac injury and its complex signaling in humans present challenges for drug development.

Purpose of the Study:

  • To provide an overview of OSM-induced cardiomyocyte remodeling.
  • To discuss the consequences of OSMR/gp130 and LIFR/gp130 activation in acute and chronic cardiac conditions.
  • To highlight the complexities of OSM signaling in human cardiac diseases.

Main Methods:

  • Review of existing literature on Oncostatin M signaling in cardiac remodeling.
  • Analysis of OSM receptor (OSMR/gp130) and leukemia inhibitory factor receptor (LIFR/gp130) complex activation.
  • Comparison of OSM signaling effects in mouse models versus human cardiac conditions.

Main Results:

  • Short-term OSMR/gp130 activation shows protective effects post-acute cardiac injury.
  • Chronic OSMR/gp130 activation promotes heart failure development.
  • OSM signaling integrates with other receptors, influencing cardiomyocyte dedifferentiation and systemic effects.

Conclusions:

  • OSM signaling complexity, involving both OSMR/gp130 and LIFR/gp130, contributes to diverse cardiac remodeling outcomes.
  • Understanding these differential effects is crucial for developing targeted pharmacological strategies for heart disease.
  • Further research into OSM's role in human cardiac pathophysiology is warranted.
Keywords:
cardiomyocytededifferentiationgp130heart failureinflammationinterleukin-6leukemia inhibitory factor receptormyocardial infarctiononcostatin M receptorremodeling

More Related Videos

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair06:37

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

8.4K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.4K

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.9K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
548
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.0K
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.1K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
90
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
56