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Updated: Oct 3, 2025
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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
Published on: March 23, 2022
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Innate Lymphoid Cells and Intestinal Inflammatory Disorders
Mingzhu Zheng1,2, Jinfang Zhu1
1Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
International Journal of Molecular Sciences
|February 15, 2022
Summary
Innate lymphoid cells (ILCs) are crucial immune cells at mucosal sites. This review explores their roles in intestinal inflammation and related disorders.
Area of Science:
- Immunology
- Cell Biology
Background:
- Innate lymphoid cells (ILCs) are lymphoid cells lacking antigen-specific receptors, residing in tissues and protecting against pathogens.
- ILCs function similarly to CD4 T helper subsets, with distinct types (ILC1, ILC2, ILC3) defined by cytokine production and transcription factors.
- ILC1s (IFN-γ, T-bet) mediate type 1 immunity, ILC2s (IL-5/IL-13, GATA3) mediate type 2 immunity, and ILC3s (RORγt, IL-22/IL-17) maintain intestinal homeostasis.
Purpose of the Study:
- To review the diverse roles of innate lymphoid cells (ILCs) in the context of intestinal inflammation.
- To highlight the significance of ILC subsets in maintaining gut health and their involvement in disease pathogenesis.
Main Methods:
- This review synthesizes current research on ILCs.
- Focuses on their functions in the gastrointestinal tract.
- Examines their involvement in inflammatory conditions.
Main Results:
- ILCs are critical for mucosal immunity and tissue-resident functions.
- Different ILC subsets (ILC1, ILC2, ILC3) orchestrate distinct immune responses.
- Dysregulation of ILCs contributes to intestinal inflammation and related disorders.
Conclusions:
- Innate lymphoid cells play multifaceted roles in intestinal immunity.
- Understanding ILC functions is key to developing therapeutic strategies for inflammatory bowel diseases.
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