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Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology
Frank Greenway1, Brian Loveridge2, Richard M Grimes3
1Clinical Trials Unit, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Physiologic insulin resensitization shows promise for treating type 2 diabetes by addressing insulin resistance. This approach may reverse diabetes complications and lower HbA1c levels.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Public Health
Background:
- Type 2 diabetes prevalence in the US rose from 2.5% in 1990 to 10.5% in 2018, posing a significant public health challenge.
- Diabetes complications include neuropathy, retinopathy, nephropathy, skin ulcers, amputations, and cardiovascular disease.
- Insulin resistance is the primary driver of type 2 diabetes, leading to beta-cell exhaustion and islet cell destruction.
Purpose of the Study:
- To evaluate the scientific basis for using physiologic insulin resensitization.
- To explore the potential of this treatment modality for type 2 diabetes.
Main Methods:
- Review of scientific literature on insulin resistance and physiologic insulin resensitization.
- Analysis of evidence supporting the efficacy of insulin resensitization in managing diabetes and its complications.
Main Results:
- Physiologic insulin resensitization addresses the core issue of insulin resistance.
- Evidence suggests this treatment can reverse complications like neuropathy, retinopathy, and nephropathy.
- The treatment modality has demonstrated an ability to lower HbA1c levels.
Conclusions:
- Physiologic insulin resensitization possesses a strong scientific foundation.
- This approach offers significant potential for treating type 2 diabetes and its complications.
- The treatment is likely to provide cost benefits.
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