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Glycerol Valorization towards a Benzoxazine Derivative through a Milling and Microwave Sequential Strategy
Miguel Ángel Torres-Pastor1, Claudia Espro2, Maurizio Selva3
1Grupo FQM-383, Departamento de Química Orgánica, Universidad de Cordoba, 14014 Cordoba, Spain.
Abstract:
Glycerol and aminophenol intermolecular condensation has been investigated through a milling and microwave-assisted sequential strategy, towards the synthesis of a benzoxaxine derivative. Mechanochemical activation prior to the microwave-assisted process could improve the probability of contact between the reagents, and greatly favors the higher conversion of aminophenol. At the same time, following a mechanochemical-microwave sequential approach could tune the selectivity towards the formation of a benzoxazine derivative, which could find application in a wide range of biomedical areas.
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