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Denervation supersensitivity and the delay phenomenon
Plastic and Reconstructive Surgery
|June 1, 1978
Summary
The denervation supersensitivity-arteriovenous shunt hypothesis poorly explains delay phenomena. Prolonged vascular smooth muscle relaxation in arterioles offers a new explanation for this delay.
Area of Science:
- Physiology
- Vascular Biology
- Surgical Research
Background:
- The delay phenomenon in AV shunts is poorly understood.
- Existing hypotheses, such as denervation supersensitivity, have limitations.
Purpose of the Study:
- To evaluate the denervation supersensitivity-AV shunt hypothesis.
- To identify the primary cause of the delay phenomenon in AV shunts.
Main Methods:
- Review of the denervation supersensitivity-AV shunt hypothesis.
- Assessment of the contribution of adrenergic denervation supersensitivity to delay.
Main Results:
- Adrenergic denervation supersensitivity contributes minimally to the delay phenomenon.
- A new hypothesis implicating precapillary arteriole smooth muscle relaxation is proposed.
Conclusions:
- The denervation supersensitivity-AV shunt hypothesis is insufficient.
- Prolonged vascular smooth muscle relaxation in precapillary arterioles is a more plausible explanation for the delay phenomenon.