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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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3,5-dinitrobenzoylhydrazone derivatives as a scaffold for antituberculosis drug development

Tamires L Valverde1, Eloísa G Sampiron1, Débora C Montaholi1

  • 1Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.

Future Microbiology
|February 15, 2022
PubMed

Keywords:
ADMEMycobacterium tuberculosisN-acylhydrazoneREMAanti-Mtb activitycheckerboardcytotoxicitymultidrug resistant

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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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