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Postoperative decrease of albumin (ΔAlb) as early predictor of complications after gastrointestinal surgery: a
Gaëtan-Romain Joliat1,2, Arnaud Schoor3, Markus Schäfer4
1Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Rue du Bugnon 46, CH-1011, Lausanne, Switzerland. gaetan.joliat@gmail.com.
The decline in serum albumin after surgery (ΔAlb) can predict postoperative complications in gastrointestinal surgery. This biomarker shows promise for early identification of patients at risk.
Area of Science:
- Surgical Outcomes
- Biomarker Discovery
- Gastrointestinal Surgery
Background:
- Postoperative complications are common after gastrointestinal surgery.
- Early prediction of these complications is a significant clinical challenge.
- Serum albumin decline (ΔAlb) post-surgery may indicate the severity of the stress response and predict complications.
Purpose of the Study:
- To systematically review the literature on the predictive value of ΔAlb for postoperative complications in gastrointestinal surgery.
Main Methods:
- A systematic review following PRISMA guidelines was conducted.
- Searches were performed in MEDLINE and Embase databases.
- Studies evaluating ΔAlb for predicting complications after gastrointestinal surgery were included.
Main Results:
- 16 studies (7 prospective, 9 retrospective) were included from 1256 screened articles.
- The sensitivity of ΔAlb ranged from 63-84% and specificity from 61-86% in predicting complications.
- Nine studies identified specific ΔAlb thresholds (5-11 g/l or 14-27%) for predicting morbidity.
Conclusions:
- ΔAlb demonstrates potential as a valuable biomarker for anticipating postoperative complications in gastrointestinal surgery.
- Further research is necessary to establish its clinical utility in perioperative patient management.
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