Related Experiment Video
Updated: Oct 3, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Grief at the Heart of the Opioid Overdose Crisis: Past Lessons and Present Implications
Kenneth L Morford1, Hannah M Batchelor, Jeanette M Tetrault
1From the Program in Addiction Medicine, Yale School of Medicine, New Haven, CT (KLM, JMT); Department of Internal Medicine, Yale School of Medicine, New Haven, CT (KLM, JMT); Yale School of Medicine, New Haven, CT (KLM, HMB, JMT).
Abstract:
Among the many people experiencing grief in response to opioid overdose deaths, individuals with opioid use disorder (OUD) bear one of the largest emotional burdens. Grief and loss of social support networks have the potential to destabilize OUD and result in overdose, suicide, and other harmful consequences. However, few clinicians discuss how overdose losses impact their patients with OUD, let alone consider the role of grief in treatment outcomes. Lessons from the acquired immunodeficiency syndrome (AIDS) epidemic and crack cocaine crisis can inform our understanding of grief in the context of stigma and societal injustices. In this commentary, we describe how these historical lessons can be adapted to the opioid overdose crisis to improve the care of people with OUD.
Related Concept Videos
Opioid Receptors: Overview
Opioid Analgesics: Morphine and Other Natural Cogeners
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Bonanno's Theory of Grieving
Resilience
Drug Abuse and Addiction: Pharmacological Phenomena

