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Related Experiment Videos

Penicillin tolerant group A streptococci.

K Krasinski, B Hanna, P LaRussa

    Diagnostic Microbiology and Infectious Disease
    |April 1, 1986
    PubMed
    Summary
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    Penicillin-tolerant Group A Streptococcus (GAS) strains were identified in a child with osteomyelitis and in healthy infants. This tolerance, which can be media-dependent, may impact treatment strategies for GAS infections.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Group A Streptococcus (GAS) is a significant human pathogen.
    • Penicillin tolerance in GAS, characterized by a significant difference between minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), is not well understood.
    • Antibiotic tolerance can impact treatment efficacy.

    Observation:

    • A child with osteomyelitis presented with a penicillin-tolerant GAS isolate.
    • Penicillin and ampicillin therapies failed to achieve a sufficient serum bactericidal effect in this patient.
    • Screening of 99 additional GAS isolates revealed that 20% exhibited penicillin tolerance under specific laboratory conditions (Mueller-Hinton broth with 2% sheep blood).

    Findings:

    • Penicillin tolerance in GAS was found to be media-dependent, with fewer strains showing tolerance in Todd-Hewitt broth compared to Mueller-Hinton broth.

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  • The minimal bactericidal concentration (MBC) for tolerant strains decreased over a 48-hour incubation period, indicating a potential for delayed bacterial killing.
  • Tolerance to penicillin in GAS appears to be more prevalent than previously assumed.

    • Implications:

    • The presence of penicillin-tolerant GAS strains may necessitate adjustments in antibiotic prophylaxis and therapeutic regimens.
    • Further research is warranted to fully understand the clinical significance of GAS tolerance and its impact on treatment outcomes.
    • Investigating the mechanisms behind GAS tolerance could lead to the development of more effective treatment strategies.