Hypertrophic Cardiomyopathy and Atrial Fibrillation: A Review

Vishnu Palyam1, Ahmad T Azam2, Oladipo Odeyinka3

  • 1Internal Medicine, Jagadguru Jayadeva Murugarajendra Medical College, Davanagere, IND.

Cureus
|February 15, 2022
PubMed

Insights

Atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) stems from diastolic dysfunction and left atrial changes. Management involves lifestyle, anticoagulation, and rhythm control to reduce mortality risks.

Area of Science:

  • Cardiology
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary inherited cardiac condition.
  • Atrial fibrillation (AF) is a common complication in HCM patients.
  • AF in HCM is linked to diastolic dysfunction and left atrial remodeling.

Purpose of the Study:

  • To examine the development and clinical impact of AF in HCM.
  • To highlight management strategies for AF in HCM.
  • To review mortality associated with AF in HCM.

Main Methods:

  • Literature review of studies on AF in HCM.
  • Analysis of clinical symptomatology and impact.
  • Examination of management approaches including lifestyle, anticoagulation, and rhythm control.

Main Results:

  • Advanced diastolic dysfunction and left atrial dilatation are key drivers of AF in HCM.
  • AF contributes to symptomatic decline, increased thromboembolism, and mortality.
  • Effective management combines lifestyle changes, anticoagulation, and rhythm control strategies.

Conclusions:

  • AF significantly impacts HCM prognosis, increasing morbidity and mortality.
  • Comprehensive management is crucial for improving outcomes in HCM patients with AF.
  • Further research into optimal AF management in HCM is warranted.

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