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Microalbuminuria as an Independent Risk Factor for Developing Concentric Left Ventricular Hypertrophy in Primary

Sayyid Moidu1, Akash T Oomen1, Gopalakrishna Pillai1

  • 1Internal Medicine, Amrita Institute of Medical Sciences and Research Centre, Kochi, IND.

Cureus
|February 15, 2022
PubMed

Insights

Microalbuminuria is a reliable marker for predicting concentric left ventricular hypertrophy (LVH) in primary hypertension patients. High serum creatinine and diastolic blood pressure also independently predict concentric LVH.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Microalbuminuria and concentric left ventricular hypertrophy (LVH) are recognized complications of primary hypertension.
  • Understanding the relationship between these conditions is crucial for managing hypertensive heart disease.

Purpose of the Study:

  • To assess if microalbuminuria is an independent risk factor for concentric LVH in primary hypertension.
  • To explore other biomarkers associated with concentric LVH in this patient group.

Main Methods:

  • A single-center observational study included adult patients with primary hypertension.
  • Data collected on microalbuminuria, LVH, serum creatinine, and diastolic blood pressure.

Main Results:

  • Microalbuminuria showed a significant association with concentric LVH (p=0.003).
  • Multivariate analysis identified microalbuminuria, serum creatinine, and high diastolic blood pressure as independent risk factors for concentric LVH (p<0.001, 0.016, 0.016).

Conclusions:

  • Microalbuminuria serves as a dependable predictor of concentric LVH in primary hypertension.
  • Elevated serum creatinine and diastolic blood pressure are also significant independent risk factors for concentric LVH.

Keywords:
concentric lvhhypertensionleft ventricular hypertrophymicroalbuminuriaprimary hypertension

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