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Native Valve Candida metapsilosis Endocarditis Following a Ruptured Appendix: A Case Report
1Department of Internal Medicine, East Tennessee State University Quillen College of Medicine, Johnson City, USA.
Cureus
|February 15, 2022
Summary
This case study details a rare instance of Candida metapsilosis endocarditis in an immunocompetent individual. Successful treatment involved valve replacement and antifungal therapy, highlighting a viable approach for this uncommon infection.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Cardiology
Background:
- The Candida parapsilosis complex includes C. parapsilosis, C. orthopsilosis, and C. metapsilosis, with C. metapsilosis being the least virulent.
- Candida endocarditis, though uncommon, carries a high mortality rate and typically affects prosthetic or damaged heart valves.
- Native, structurally normal heart valves are rarely implicated in Candida endocarditis.
Observation:
- A case of Candida metapsilosis endocarditis involving a native aortic valve is presented.
- The affected individual was a 55-year-old immunocompetent male.
- The patient presented with symptoms indicative of endocarditis.
Findings:
- Successful treatment was achieved through a combination of surgical aortic valve replacement and targeted antifungal therapy.
- This case demonstrates the successful management of a rare fungal endocarditis involving a less virulent Candida species on a native valve.
- The patient's immunocompetent status and the specific fungal species influenced the treatment approach and outcome.
Implications:
- This case expands the understanding of Candida metapsilosis as a potential pathogen in native valve endocarditis, even in immunocompetent hosts.
- The successful surgical and antifungal management strategy provides a valuable clinical precedent for similar rare cases.
- Further research into the virulence factors and treatment nuances of Candida metapsilosis in endocarditis is warranted.
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