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ENETS standardized (synoptic) reporting for neuroendocrine tumour pathology
Marie-Louise F van Velthuysen1, Anne Couvelard2, Guido Rindi3,4,5
1Department Pathology, Erasmus MC, Rotterdam, The Netherlands.
Journal of Neuroendocrinology
|February 15, 2022
Summary
Standardized reporting templates for neuroendocrine neoplasms (NEN) were developed by European experts. These templates aim to improve tumor report comparability and reduce confusion from evolving WHO classifications.
Area of Science:
- Oncology
- Pathology
- Medical Diagnostics
Background:
- The World Health Organization (WHO) classification of neuroendocrine neoplasms (NEN) has undergone recent changes, impacting nomenclature and grading thresholds.
- These evolving classifications can lead to confusion and a lack of comparability in tumor reports.
- Standardized reporting is crucial for accurate diagnosis, treatment, and research in NEN.
Purpose of the Study:
- To develop standardized pathology data set templates for reporting common neuroendocrine neoplasms (NEN).
- To address the confusion and lack of comparability arising from evolving WHO classifications.
- To facilitate unambiguous and consistent reporting of NEN across different institutions.
Main Methods:
- An interdisciplinary working group, including members of the European Neuroendocrine Tumour Society (ENETS) Advisory Board, was established.
- Templates were developed based on the WHO classification of digestive system tumors, lung and mediastinum tumors, and ENETS Standard of Care reports.
- Synoptic reporting templates were created for seven common NEN primary sites (stomach, duodenum, jejunum-ileum, appendix, colon-rectum, pancreas, lung, mediastinum) and a general biopsy template.
Main Results:
- Templates for synoptic reporting were developed for the most common NEN primary sites and for biopsies.
- The templates facilitate the recording of essential items including differentiation, proliferation (Ki-67, mitosis), neuroendocrine features (chromogranin A, synaptophysin), and staging.
- Optional markers are included to aid in distinguishing neuroendocrine tumors (NET) from neuroendocrine carcinomas (NEC).
Conclusions:
- The developed synoptic reporting templates provide a standardized framework for NEN pathology reports.
- These templates, created by a multidisciplinary team of international experts, aim to improve the clarity and consistency of NEN reporting.
- Implementation of these templates is expected to enhance the comparability of tumor reports and aid in clinical decision-making for NEN patients.
