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Norfloxacin: a quinoline antibiotic.

D A Marble, J A Bosso

    Drug Intelligence & Clinical Pharmacy
    |April 1, 1986
    PubMed
    Summary

    Norfloxacin, a quinoline antibiotic, shows potent activity against gram-positive and gram-negative bacteria, offering a promising oral alternative to intravenous treatments. Clinical studies indicate minimal side effects in over 4000 patients.

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    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Antibiotic Research

    Background:

    • Norfloxacin is a quinolinecarboxylic acid derivative with broad-spectrum antibacterial properties.
    • It demonstrates superior activity compared to nalidixic acid and other common antibiotics.
    • Potential for treating infections requiring hospitalization and intravenous antibiotics.

    Purpose of the Study:

    • To evaluate the efficacy and safety of norfloxacin as an oral antibiotic treatment.
    • To compare the antibacterial potency of norfloxacin against various classes of antimicrobial agents.

    Main Methods:

    • Clinical studies involving over 4000 patients.
    • Comparative analysis of norfloxacin's antibacterial spectrum and potency.
    • Assessment of side effect incidence and characteristics.

    Main Results:

    • Norfloxacin exhibits greater antibacterial activity against both gram-positive and gram-negative bacteria than many established antibiotics.
    • Potency is higher than aminoglycosides, cephalosporins, tetracycline, trimethoprim-sulfamethoxazole, and others.
    • Minimal side effects were observed, with an incidence of 3.9-4.7%.

    Conclusions:

    • Norfloxacin is a potent oral antibiotic effective against a wide range of bacteria.
    • It presents a viable alternative to intravenous antibiotics for various infections.
    • The drug is well-tolerated with a low incidence of adverse effects.

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