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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

41
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

44
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Related Experiment Video

Updated: Oct 3, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
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Peripheral neuropathy and livedoid vasculopathy.

Antoine Soulages1, Thierry Maisonobe2, Pascal Auzou3

  • 1Department of Neurology, Nerve-Muscle Unit, Referral Center for Neuromuscular Diseases AOC, University Hospital of Bordeaux (CHU Bordeaux, Pellegrin Hospital), Bordeaux, France.

Journal of Neurology
|February 15, 2022
PubMed
Summary

Livedoid vasculopathy (LV) can cause peripheral neuropathy, often presenting as mononeuropathy multiplex. This ischemic neuropathy, distinct from vasculitic forms, primarily affects sensation and requires careful diagnosis.

Keywords:
LivedoidMononeuropathyPeripheral neuropathyVasculitisVasculopathy

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Area of Science:

  • Dermatology
  • Neurology
  • Pathology

Background:

  • Livedoid vasculopathy (LV) is a chronic skin condition characterized by micro-thrombosis in dermal vessels, leading to painful ulcers.
  • This condition, distinct from classical vasculitis, can result in peripheral neuropathy.

Purpose of the Study:

  • To define the clinical, electrophysiological, and pathological features of peripheral neuropathy associated with LV.
  • To differentiate LV-related neuropathy from other neuropathic conditions.

Main Methods:

  • Case series of peripheral neuropathy in LV patients.
  • Systematic literature review using PubMed, Google Scholar, and ScienceDirect databases.

Main Results:

  • Sixteen patients (6 personal, 10 literature) were identified.
  • The predominant pattern of neuropathy was mononeuropathy multiplex, affecting sensation and sometimes motor function.
  • Median age at onset of neuropathy symptoms was 48 years.

Conclusions:

  • Peripheral neuropathy in LV typically presents as mononeuropathy multiplex, likely due to small vessel occlusion in nerves.
  • Distinguishing this ischemic neuropathy from autoimmune-related neuropathies is crucial for appropriate treatment.
  • LV-associated neuropathy requires differentiation from classical vasculitic neuropathies.