Related Experiment Video

Updated: Oct 3, 2025

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.3K

The Use of Targeted Agents in the Treatment of Gynecologic Cancers

Shaina F Bruce1, Matthew A Powell2

  • 1Division of Gynecologic Oncology, Washington University, 660 S. Euclid Avenue, Mailstop 8064-37-905, Saint Louis, MO, 63110, USA. brucesf@wustl.edu.

Current Treatment Options in Oncology
|February 15, 2022
PubMed
Abstract

Insights

Targeted therapies offer new options for advanced gynecologic cancers, including ovarian, uterine, and cervical. Combination therapies and biomarker research are crucial for improving patient outcomes in these challenging cases.

Area of Science:

  • Gynecologic Oncology
  • Medical Oncology
  • Translational Cancer Research

Background:

  • Advanced and recurrent ovarian, uterine, and cervical cancers present limited treatment options and poor prognoses.
  • Targeted therapies focusing on DNA repair, angiogenesis, immune checkpoints, and hormone receptors are emerging.
  • Many targeted agents show limited efficacy as monotherapies, necessitating combination strategies.

Purpose of the Study:

  • To review recent evidence on clinically available targeted therapies for gynecologic cancers.
  • To highlight the importance of combination therapies and predictive biomarkers.
  • To discuss novel therapeutic agents under development.

Main Methods:

  • Literature review of recent clinical evidence.
  • Focus on clinically available targeted therapies.
  • Discussion of ongoing and future therapeutic developments.

Main Results:

  • Targeted agents targeting DNA repair, angiogenesis, immune checkpoints, and hormone receptors offer new avenues.
  • Combination therapies are critical for enhancing efficacy.
  • Identification and validation of predictive biomarkers are essential for personalized treatment.

Conclusions:

  • Targeted therapies represent a significant advancement in treating advanced gynecologic cancers.
  • Clinical trials exploring combination regimens and biomarkers are vital for improving patient outcomes.
  • Ongoing development of novel small molecules, antibody-drug conjugates, and vaccines holds promise.
Keywords:
Anti-angiogenicsGynecologic cancerHormonal therapyImmunotherapyPARP inhibitorTargeted therapy

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.3K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.4K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
711
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K