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Published on: December 3, 2017
Predictive Algorithms in the Diagnosis and Management of Pediatric Hip and Periarticular Infection
Sarah Hunter1, Georgina Kioa2, Joseph F Baker1,3
1Department of Orthopaedic Surgery, Waikato Hospital, Hamilton, New Zealand.
Insights
Current diagnostic criteria for septic arthritis are insufficient. New algorithms for predicting bone and joint infections in children are emerging, but require careful validation before clinical adoption.
Area of Science:
- Pediatric Orthopedics
- Infectious Diseases
- Medical Diagnostics
Background:
- Kocher criteria for hip septic arthritis diagnosis are outdated due to evolving microbes and advanced imaging.
- Disseminated disease and osteomyelitis are increasingly recognized alongside septic arthritis, necessitating new diagnostic approaches.
- Advanced imaging like MRI has improved detection of concurrent osteoarticular infections.
Purpose of the Study:
- To evaluate the current diagnostic criteria for septic arthritis.
- To highlight the need for updated algorithms in pediatric bone and joint infections (BJI).
- To emphasize the importance of external validation for clinical prediction algorithms in childhood BJI.
Main Methods:
- Review of existing diagnostic criteria for septic arthritis.
- Analysis of the impact of advanced imaging on diagnosing bone and joint infections.
- Assessment of emerging clinical prediction algorithms for childhood BJI.
- Discussion of the methodological quality of current predictive algorithms.
Main Results:
- Traditional criteria for septic arthritis are no longer sufficient for early diagnosis.
- Clinical prediction algorithms are being developed to identify concurrent osteoarticular infections.
- Stratification of childhood bone and joint infection (BJI) by severity is crucial for treatment planning.
- The methodology of many childhood BJI prediction algorithms lacks robustness.
Conclusions:
- Contemporary clinical practice requires diagnostic tools beyond the original Kocher criteria.
- Development of predictive algorithms for childhood BJI is advancing, but methodological rigor is variable.
- Clinicians must exercise caution and ensure robust external validation before implementing new predictive algorithms for childhood bone and joint infections.
Abstract:
➤ Although the criteria of Kocher et al. were an important advancement in our ability to diagnose septic arthritis of the hip early, the changing microbial landscape and availability of advanced imaging have rendered it insufficient for contemporary clinical use.➤ Routine use of magnetic resonance imaging and recognition of disseminated disease have prompted the development of algorithms to predict concurrent osteoarticular infection in cases of septic arthritis and osteomyelitis that were previously assumed to be "isolated."➤ Recent research has attempted to stratify childhood bone and joint infection (BJI) by severity to guide treatment planning. This is valuable, as patients with multifocal disease, more virulent pathogens, and immunocompromise can have longer hospital stays and require multiple surgeries.➤ The increasing prevalence of clinical prediction algorithms in childhood BJI is not completely matched by quality in methodology. Clinicians need to be wary of adopting predictive algorithms prior to robust external validation.
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