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Doppler Optical Coherence Tomography of Retinal Circulation

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Full-range optical coherence refraction tomography.

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Full-range optical coherence refraction tomography (FROCRT) enhances imaging by reconstructing isotropic resolution images with an extended depth range. This novel method overcomes limitations in traditional optical coherence tomography for broader biomedical applications.

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Area of Science:

Biomedical Imaging
Optical Engineering

Background:

Full-range optical coherence tomography (FROCT) exhibits superior axial over lateral resolution, which is degraded by signal processing and depth-dependent defocus effects.
Optical coherence refraction tomography (OCRT) addresses resolution anisotropy by computationally reconstructing images from multiple angles, achieving isotropic resolution within a sub-millimeter depth range.

Purpose of the Study:

To introduce and validate full-range optical coherence refraction tomography (FROCRT).
To achieve isotropic spatial resolution with an extended imaging range by utilizing full-range complex conjugate-free OCT images from multiple angles.

Main Methods:

Development of a system for automatic 360° image acquisition for reconstruction.
Application of FROCRT using full-range complex conjugate-free OCT images from multiple angles.
Computational reconstruction of images to achieve isotropic resolution and extended imaging depth.

Main Results:

Demonstrated extended imaging depth and isotropic resolution.
Successful application of FROCRT to tape phantom, optical-cleared mouse leg bone, spinal cord, and aloe samples.
Validation of the FROCRT system's capability for high-resolution, extended-depth imaging.

Conclusions:

FROCRT successfully extends the imaging range and achieves isotropic resolution.
The proposed FROCRT method overcomes limitations of traditional OCT and OCRT.
FROCRT is poised to enable a broader range of applications in biomedical imaging.