Related Experiment Video
Updated: Jul 26, 2026

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
Cardiovascular disease in the elderly: proceedings of the European Society of Cardiology-Cardiovascular Round Table
Maddalena Lettino1, Julia Mascherbauer2, Matias Nordaby3
1Cardiovascular Department, San Gerardo Hospital of Monza, Via G. B. Pergolesi, 33, 20900 Monza MB, Italy.
Insights
Caring for aging populations with cardiovascular disease requires better strategies. Clinical trials must include older adults, focusing on quality of life and real-world outcomes for effective prevention and management.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Public Health
Background:
- The global elderly population is increasing, presenting challenges in healthcare and societal support.
- Older adults exhibit a higher prevalence of cardiovascular (CV) disease, numerous CV risk factors, and age-related comorbidities.
- Current CV prevention and management strategies are under-utilized and under-studied in the elderly population.
Purpose of the Study:
- To highlight the growing impact of aging on cardiovascular health and the need for enhanced primary prevention.
- To discuss considerations for pharmacological and interventional treatments in elderly patients.
- To emphasize the importance of quality of life and patient priorities in clinical decision-making for older adults.
Main Methods:
- Review of current literature on cardiovascular disease in aging populations.
- Analysis of challenges in clinical trial inclusion and outcome assessment for older adults.
- Discussion of real-world evidence and multidisciplinary care approaches.
Main Results:
- Older patients require tailored approaches considering frailty, cognitive status, and quality of life alongside longevity.
- Clinical trials often underrepresent older adults, necessitating a greater focus on real-world studies for long-term outcomes, particularly safety and quality of life.
- Multidisciplinary care and patient involvement in decision-making are crucial for optimizing CV care in the elderly.
Conclusions:
- Addressing the cardiovascular needs of the aging population requires a shift towards inclusive clinical research and personalized treatment strategies.
- Continued primary prevention efforts targeting CV risk factors are essential.
- Integrating patient-centered goals, including quality of life, into treatment plans is paramount for effective elderly cardiovascular care.
Abstract:
The growing elderly population worldwide represents a major challenge for caregivers, healthcare providers, and society. Older patients have a higher prevalence of cardiovascular (CV) disease, high rates of CV risk factors, and multiple age-related comorbidities. Although prevention and management strategies have been shown to be effective in older people, they continue to be under-used, and under-studied. In addition to hard endpoints, frailty, cognitive impairments, and patients' re-assessment of important outcomes (e.g. quality of life vs. longevity) are important aspects for older patients and emphasize the need to include a substantial proportion of older patients in CV clinical trials. To complement the often skewed age distribution in clinical trials, greater emphasis should be placed on real-world studies to assess longer-term outcomes, especially safety and quality of life outcomes. In the complex environment of the older patient, a multidisciplinary care team approach with the involvement of the individual patient in the decision-making process can help optimize prevention and management strategies. This article aims to demonstrate the growing burden of ageing in real life and illustrates the need to continue primary prevention to address CV risk factors. It summarizes factors to consider when choosing pharmacological and interventional treatments for the elderly and the need to consider quality of life and patient priorities when making decisions.
Related Concept Videos
Pharmacodynamics in Geriatric Patients: Effects of Age
Rheumatic Heart Disease III: Medical Management
Coronary Artery Disease IV: Preventive Measures
Coronary Artery Disease V: Interprofessional Care
Cardiomyopathy V: Interprofessional Care
Peripheral Artery Disease III: Interprofessional Care

