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A research of preoperative neurocognitive functioning and contributing factors in patients with supratentorial
Lixin Wang1, Shengyu Fang2, Yuming Peng1
1Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Objective:
The purpose of this study was to investigate the neurocognitive function of patients with supratentorial glioma and the sociodemographic and tumor characteristics that affect neurocognitive function preoperatively.
Methods:
In the present study, we performed completed comprehensive neuropsychological assessments in patients older than 18 years in Beijing Tiantan Hospital, which is affiliated with Capital Medical University. Patients were initially diagnosed with supratentorial glioma by MRI examination. Neuropsychological assessments were based on eight variables from six neuropsychological tests: Auditory Verbal Learning Test (AVLT), Trail Making Test (TMT), Stroop Test (Stroop), Symbol Digital Modalities Test (SDMT), Verbal Fluency Test (VFT), and Boston Naming Test (BNT).
Analysis:
(1) whether supratentorial glioma patients and healthy control group is different in neurocognitive functioning before operation, (2) Logistic regression analyses were performed to evaluated the value of patient-, tumor-related factors influencing neurocognitive functioning before operation.
Results:
Compared with healthy controls, the patients with supratentorial glioma had worse performance in the neurocognitive function. In the univariate analyses, among all glioma patients, compared to patients with non-impaired cognitive function, patients with impaired cognitive function had significantly differences in terms of age, years of education, tumor volume and pathological grade. Logistic regression analysis showed that older age and larger tumor size were factors affecting cognitive dysfunction in patients with glioma. Whereas, high education was a protective factor for neurocognitive function.
Conclusion:
Extensive neurocognitive dysfunction was present in both left- and right-sided glioma patients and may be closely related to advanced age, and large tumor volume. An understanding of these risk factors may be important in determining proper treatment protocols to improve cognitive function and quality of life.
