Related Experiment Video
Updated: Oct 3, 2025
08:14
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
15.8K
MicroRNAs as Biomarkers for Birth Defects.
Ratnam S Seelan1, M Michele Pisano1, Robert M Greene1
1Department of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, School of Dentistry, University of Louisville, Louisville, KY 40202, USA.
Microrna (Shariqah, United Arab Emirates)
|February 16, 2022
Summary
Extracellular microRNAs (miRNAs) show promise as noninvasive prenatal biomarkers for detecting birth defects (BDs). Research is exploring their potential for early risk assessment and improved management of these conditions.
Area of Science:
- Biochemistry
- Genetics
- Reproductive Medicine
Background:
- Birth defects (BDs) affect 2-4% of live births, necessitating improved detection methods.
- Extracellular microRNAs (miRNAs), encapsulated in exosomes, are released by fetal and placental cells.
- These exosomal miRNAs are stable, functional, and detectable in maternal circulation, offering a potential noninvasive biomarker source.
Purpose of the Study:
- To review the current research on using miRNAs as biomarkers for prenatal detection of birth defects.
- To assess the potential of extracellular miRNAs for early risk assessment and management of BDs.
Main Methods:
- Literature review of studies investigating miRNA expression in relation to birth defects.
- Analysis of research on exosomal miRNAs as noninvasive prenatal diagnostic tools.
Main Results:
- Altered miRNA expression is linked to various diseases, suggesting their role in BDs.
- Placental and fetal miRNAs are detectable in maternal serum, supporting their use as biomarkers.
- Exosomal miRNAs are protected from degradation and retain functionality, enhancing their biomarker potential.
Conclusions:
- Extracellular miRNAs hold significant promise as noninvasive prenatal biomarkers for birth defects.
- Further research is needed to validate their diagnostic and prognostic capabilities for BDs.
