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The diterpenoid alkaloids.

Xiao-Yu Liu1, Bo-Wen Ke2, Yong Qin1

  • 1Department of Chemistry of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu, China; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, China.

The Alkaloids. Chemistry and Biology
|February 16, 2022
PubMed
Summary
This summary is machine-generated.

This review covers diterpenoid alkaloids, focusing on new structures and biological activities from 2009-2019. It details chemical reactions, synthetic studies, and classification for a comprehensive profile.

Keywords:
Biological activityChemical reactionClassificationDiterpenoid alkaloidNatural productPhytochemistryTotal synthesis

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Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Medicinal Chemistry

Background:

  • Diterpenoid alkaloids are crucial natural products with complex structures and varied biological effects.
  • These compounds have been a significant focus in scientific research due to their potential applications.

Purpose of the Study:

  • To systematically review studies on diterpenoid alkaloids from 2009 to 2019.
  • To provide an updated profile of diterpenoid alkaloids, including atypical variants.
  • To consolidate knowledge with previous reviews for a comprehensive overview.

Main Methods:

  • Literature review of diterpenoid alkaloid research from 2009-2019.
  • Analysis of classification, biogenetic relationships, and phytochemistry.
  • Examination of chemical reactions, synthetic studies, and biological activities.

Main Results:

  • Summarized 444 new diterpenoid alkaloids, including 32 novel skeletons and corrected structures.
  • Reviewed chemical reactions, including conversion to toxoids.
  • For the first time, comprehensively reviewed synthetic studies and total syntheses of diterpenoid alkaloids.

Conclusions:

  • The review provides an updated and comprehensive profile of diterpenoid alkaloids.
  • It highlights significant advancements in the understanding of their structures, synthesis, and activities.
  • This work serves as a valuable resource for researchers in natural product chemistry.