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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

330
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
330
Seizures: Classification01:13

Seizures: Classification

644
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
644

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Related Experiment Video

Updated: Oct 3, 2025

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
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Multicentre observational status-epilepticus registry: protocol for ICTAL.

Gwenaelle Jacq1, Jonathan Chelly2, Jean-Pierre Quenot3

  • 1Service de réanimation et unité de soins continus, Centre Hospitalier de Versailles, Le Chesnay, France.

BMJ Open
|February 16, 2022
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Summary

Status epilepticus (SE) is a critical neurological emergency with poor outcomes. The ICTAL Registry collects data to understand SE causes and improve patient treatment strategies.

Keywords:
adult intensive & critical careadult neurologyepidemiology

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Area of Science:

  • Neurology
  • Critical Care Medicine
  • Epidemiology

Background:

  • Status epilepticus (SE) is a life-threatening neurological emergency associated with significant long-term impairments and poor overall outcomes.
  • There is a critical need to understand the epidemiology of SE and factors influencing patient outcomes to identify targets for improved management strategies.

Purpose of the Study:

  • To establish the ICTAL Registry, a multicentre open cohort study for critically ill patients experiencing various forms of SE.
  • To collect high-quality, uniform data on a large patient cohort to elucidate pathophysiological mechanisms underlying SE-related mortality and morbidity.
  • To facilitate subgroup analyses for identifying specific patient populations that may benefit from tailored treatment strategies.

Main Methods:

  • Utilizing observational methods within a multicentre open cohort design.
  • Implementing a modular registry structure with a comprehensive core dataset and flexible satellite datasets for diverse study types (e.g., RCTs, cross-sectional, longitudinal outcomes).
  • Ensuring data quality and uniformity through standardized data collection protocols.

Main Results:

  • The ICTAL Registry is designed to enable valid subgroup analyses due to the large patient volume and comprehensive data.
  • The collected data will allow for the elucidation of pathophysiological mechanisms contributing to mortality and morbidity in SE.
  • The registry's structure aims to reduce costs and hasten patient recruitment for various research studies.

Conclusions:

  • The ICTAL Registry provides a robust platform for advancing the understanding and management of status epilepticus.
  • Multidisciplinary research through the IctalGroup network will broaden the applicability of study findings.
  • The registry's data dissemination via publications and presentations will contribute to the scientific community's knowledge base on SE.