The interaction of central acting drugs with glutamate dehydrogenase

The neuroleptics chlorpromazine, fluphenazine, triflupromazine and thioridazine seem to effect the aggregation of glutamate dehydrogenase by binding to one single site of the polypeptide chain, possibly the GTP site. This interaction could biologically be of importance for the degree of activity at high enzyme concentrations found in vivo. Amitriptyline and fluorazepam also bind to a specific single site of the polypeptide chain without effecting the aggregation of the oligomers. Because of the rather low affinity of these sites the binding of these drugs in vivo does not seem to cause a concentrating effect in the mitochondria.