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Adenoma Detection Rates in 45-49-Year-Old Persons Undergoing Screening Colonoscopy: Analysis From the GIQuIC

Mohammad Bilal¹, Jennifer Holub², David Greenwald³

¹Division of Gastroenterology & Hepatology, Minneapolis VA Medical Center, University of Minnesota, Minneapolis, Minnesota, USA.

The American Journal of Gastroenterology

|February 16, 2022

Summary

Lowering the colon cancer screening age to 45 may slightly decrease the adenoma detection rate (ADR) for endoscopists. This study analyzed over 2.8 million colonoscopies to assess the impact on ADR in younger screening populations.

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Area of Science:

Gastroenterology
Preventive Medicine
Public Health

Background:

The recommended age for initiating colon cancer screening has been lowered to 45 years for average-risk individuals.
The effect of this age reduction on the adenoma detection rate (ADR) among endoscopists is not well understood.

Purpose of the Study:

To investigate the impact of lowering the colon cancer screening age to 45 years on the adenoma detection rate (ADR) observed by endoscopists.
To compare ADRs across different age groups undergoing screening colonoscopy.

Main Methods:

Analysis of 2,806,539 average-risk screening colonoscopies from 2014-2020.
Data sourced from the GI Quality Improvement Consortium registry, including individuals aged 45-75.
One-way ANOVA test used to compare ADRs between age groups: 45-49, 50-54, and 50-75 years.

Main Results:

The mean ADR for the 45-49-year-old group was 28.6%.
The mean ADR for the 50-54-year-old group was 31.8% (P < 0.001).
The mean ADR for the 50-75-year-old group was 36.3% (P < 0.001).

Conclusions:

A statistically significant difference in ADR was observed between the age groups.
Endoscopists may experience a slight decrease in their ADR as more patients aged 45-49 undergo screening colonoscopy.