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Update Breast Cancer 2021 Part 5 - Advanced Breast Cancer

Diana Lüftner1, Florian Schütz2, Elmar Stickeler3

  • 1Charité University Hospital, Department of Hematology, Oncology and Tumour Immunology, University Medicine Berlin, Berlin, Germany.

Geburtshilfe Und Frauenheilkunde
|February 16, 2022
PubMed

Insights

Innovations in breast cancer treatment continue, with new data on CDK4/6 inhibitors and improved progression-free survival from trastuzumab-deruxtecan. Research also advances in biomarkers and oral selective estrogen receptor destabilisers (SERDs).

Area of Science:

  • Oncology
  • Medical research

Background:

  • Despite the COVID-19 pandemic, advancements in breast cancer treatment persist.
  • Progress includes new therapeutic strategies and a deeper understanding of treatment efficacy.

Purpose of the Study:

  • To review current developments in breast cancer treatment.
  • To summarize recent clinical trial findings and emerging therapies.

Main Methods:

  • Review of recently published clinical trial data.
  • Analysis of emerging therapeutic agents and biomarker research.

Main Results:

  • Initial overall survival data for CDK4/6 inhibitors combined with aromatase inhibitors in treatment-naive postmenopausal patients are available.
  • Trastuzumab-deruxtecan demonstrated a progression-free survival benefit over trastuzumab-emtansine.
  • Understanding of biomarkers for checkpoint inhibitor therapy is improving.
  • Oral selective estrogen receptor destabilisers (SERDs) are progressing through clinical trials.

Conclusions:

  • The pace of innovation in breast cancer treatment remains high.
  • New therapies and a better understanding of biomarkers are enhancing patient outcomes.
Keywords:
BRCA (breast cancer associated gene)Her-2/neu (human epidermal growth factor receptor)breastbreast cancergeneticshormonal receptor

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