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Updated: Aug 14, 2026
04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Impact of improved local control on survival
Summary
Improving local cancer treatment could significantly increase survival rates. Enhanced local control, by reducing distant metastases, offers more opportunities for patient cures, especially for specific cancer types.
Area of Science:
- Oncology
- Cancer Research
- Treatment Efficacy
Background:
- Local treatment failures contribute to cancer mortality.
- Distant metastases (DM) are often linked to persistent local disease.
- Salvage surgery for local failures shows potential for long-term survival.
Purpose of the Study:
- To estimate survival gains from eliminating local cancer failures.
- To assess the impact of improved local-regional therapy efficacy.
- To identify cancer types with significant potential survival benefits.
Main Methods:
- Survival gain estimation based on local control rates.
- Analysis of distant metastases incidence in relation to local control.
- Literature review of survival outcomes with effective local therapies.
Main Results:
- Eliminating local failures could substantially improve cure rates.
- Higher local control rates are associated with increased survival.
- Significant survival gains are possible for uterine cervix, oral cavity, ovarian, colorectal, lung, prostate, and bladder cancers.
Conclusions:
- Improving local-regional cancer therapy is crucial for increasing patient survival.
- Aggressive investigation into new local-regional treatment approaches is warranted.
- For certain cancers, enhanced local control offers a powerful strategy for improving cure rates.
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