Related Experiment Video

Updated: Oct 3, 2025

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

3.7K

Efficacy of awake prone positioning for severe illness coronavirus disease 2019 patients: a propensity score-adjusted

Kenji Numata1, Daiki Kobayashi2, Tomohiro Hosoda3

  • 1Department of Emergency and Critical Care Medicine St Marianna University School of Medicine Kawasaki Japan.

Acute Medicine & Surgery
|February 16, 2022
PubMed

Insights

Awake prone positioning (PP) significantly reduced intubation rates in severe COVID-19 patients receiving standard therapy. This intervention shows promise for preventing mechanical ventilation in critically ill coronavirus disease 2019 patients.

Area of Science:

  • Critical Care Medicine
  • Pulmonology
  • Infectious Diseases

Background:

  • Awake prone positioning (PP) improves oxygenation in COVID-19 patients.
  • Evidence for PP preventing intubation in COVID-19 is limited.
  • This study evaluates awake PP in patients receiving remdesivir, dexamethasone, and anticoagulants.

Purpose of the Study:

  • To investigate the efficacy of awake prone positioning (PP) in preventing intubation.
  • To assess the impact of awake PP on intubation rates and length of stay.
  • To analyze outcomes in severe COVID-19 patients treated with specific therapies.

Main Methods:

  • Two-center cohort study design.
  • Inclusion of patients admitted to a severe COVID-19 unit.
  • Propensity score adjustment and multivariable regression analysis.

Main Results:

  • Awake PP was associated with a significantly lower intubation rate (9.3% vs. 37.0%).
  • After propensity score adjustment, awake PP showed a reduced odds ratio for intubation (0.22).
  • Length of stay in the severe COVID-19 unit did not significantly differ between groups.

Conclusions:

  • Awake prone positioning may correlate with reduced intubation rates in COVID-19 patients on specific therapies.
  • Awake PP is a potential strategy to avoid mechanical ventilation in severe COVID-19.
  • Further research is warranted to confirm these findings.
Abstract

Keywords:
Coronavirus disease 2019dexamethasoneintubationprone positioningrespiratory failure

More Related Videos

Prone Lateral Minimally Invasive Retropleural Corpectomy Using a Rotatable Radiolucent Jackson Table04:57

Prone Lateral Minimally Invasive Retropleural Corpectomy Using a Rotatable Radiolucent Jackson Table

Published on: July 3, 2025

517
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.9K

Related Concept Videos

Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
417
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
372
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
378
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
225
Anatomical Positions01:11

Anatomical Positions

In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
16.4K
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
257