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Updated: Oct 3, 2025

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft

Published on: February 14, 2022

"It Works." Every heart transplant program should have one.

Jack G Copeland¹, Hannah Copeland^2,3

¹Banner University Medical Center, University of Arizona, Tucson, Arizona, USA.

Journal of Cardiac Surgery

|February 16, 2022

Summary

This summary is machine-generated.

The total artificial heart (TAH) offers full cardiac replacement, enabling organ recovery and improving transplant candidacy. TAH recipients can achieve mobility and rehabilitation, potentially saving lives.

Keywords:

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Area of Science:

Cardiovascular Surgery
Medical Devices

Background:

End-stage heart failure necessitates advanced circulatory support.
Current treatments have limitations for many cardiac patients.

Purpose of the Study:

To evaluate the efficacy and safety of the total artificial heart (TAH) for biventricular cardiac replacement.
To assess the potential of TAH to improve outcomes for heart transplant candidates.

Main Methods:

Utilized total artificial heart (TAH) for full biventricular cardiac replacement.
Monitored pulsatile perfusion at 7-9 L/min with low filling pressures.

Main Results:

TAH provides complete cardiac replacement with adequate perfusion.
Facilitates organ recovery in failing organs.
Enables patient mobility and physical rehabilitation post-implantation.
Associated risks were deemed acceptable.

Conclusions:

Total artificial heart (TAH) is a viable option for biventricular cardiac replacement.
TAH can enhance organ recovery and improve transplant candidacy.
Wider adoption of TAH could increase survival rates for transplant candidates.