Related Experiment Video
Updated: Oct 3, 2025
09:14
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
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Endocrine dysregulation in aneurysmal subarachnoid haemorrhage
Thomas Roe1, Jessie Welbourne1, Nikitas Nikitas1
1Department of Intensive Care Medicine, Derriford Hospital, University Hospitals Plymouth NHS Trust, Plymouth, UK.
British Journal of Neurosurgery
|February 16, 2022
Summary
Endocrine dysregulation is common after aneurysmal subarachnoid haemorrhage (aSAH), potentially worsening outcomes. Further research is needed to clarify the causes and mechanisms of this dysregulation and its impact on aSAH complications.
Area of Science:
- Neurocritical care
- Endocrinology
- Neurosurgery
Background:
- Aneurysmal subarachnoid haemorrhage (aSAH) frequently leads to neurocritical care admission.
- Endocrine system dysregulation is consistently observed in aSAH patients.
Purpose of the Study:
- To review current evidence on endocrine dysregulation in aSAH.
- To explore the association between endocrine changes and patient outcomes.
Main Methods:
- Comprehensive literature search of PubMed.
- Review of studies published since 2010 on hypothalamic-pituitary, adrenal, and natriuretic peptide hormones.
- Focus on endocrine dysregulation post-aSAH.
Main Results:
- Variable prevalence of hypothalamic-pituitary and adrenal hormone dysregulation reported.
- Dysregulation linked to poorer neurological outcomes and increased mortality.
- Potential causal link between endocrine issues and hyponatremia/delayed cerebral ischemia.
Conclusions:
- Evidence suggests adverse effects of endocrine dysregulation on aSAH outcomes and complications.
- The precise causes and pathophysiological mechanisms remain unclear.
- Further research is essential to determine the clinical significance of endocrine dysregulation in aSAH.
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